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Logo Ateneo
   
Spinozzi Giulio
Giulio Spinozzi, M.Sc.
Giulio Spinozzi, M.Sc.

PostDoc Fellowship (ERC Funded)

Department of Medicine, Hematology - University of Perugia

Group Leader: Prof.ssa Maria Paola Martelli

 



Bioinformatics Engineer

Vector Integration Core, Telethon Institute for Gene Therapy - San Raffaele Scientific Institute, Milan

Group Leader: Dr. Eugenio Montini

Research interests and skills

Systems Biology: Dynamical and generic properties of biological networks; models of catalytic reaction networks; multiscale models of biological systems; causal models of disease progression;

Bioinformatics: NGS data analysis (DNA, Chip-Seq, RNA-Seq, CRISPR-Cas9), vector integration studies in gene therapy; data mining; biobanks; scripting

Informatics: Software engineering; modelling; databases; operating systems

Control Systems: mico-controllers; processes control; robotics; dynamics modelling; systems theory

Short Bio
Giulio Spinozzi has completed his Master's Degree in Computer and Automation Engineering from University of Perugia, Italy, and Bachelor's Degree in Informatics and Electronics Engineering from University of Perugia, Italy.
While studying he is trying to improve his skills in all important areas which have direct or indirect link to Systems Biology and Computer Science domains which flourished more while working, as Research Assistant, in Service and Industrial Robotics and Automation Laboratory (SIRALab) and as fellow in Medical Oncology, Hospital of Perugia Then he got the opportunity to work, as Bioinformatics Engineer, at the Telethon Institute for Gene Therapy, in particular in the Vector Integration Core. In the meanwhile he has taken the PhD at University of Milano-Bicocca with a thesis titled: "Anti-Cancer Drug Resistance Causal Modeling from Lentiviral-Vector Integration Site Studies". In the middle of 2017 He won a PhD Fellowship (ERC funded) at the University of Perugia, in the Hematology division of Prof. Maria Paola Martelli and Prof. Brunangelo Falini. 
Grants and Awards
  • 2018 - Italian SuperComputing Resource Allocation sponsored by CINECA for AML studies, Unipg. - 25000 on MARCON1 - HP10CZ1LLU - P.I. Eng. Giulio Spinozzi 
  • 2016 - Bioinformatics Italian Society, annual meeting 2016 - Travel Grant
Research Publications
  • Calabria, A.*, Leo, S.*, Benedicenti, F., Cesana, D., Spinozzi, G.,  Orsini, M., Merella, S., Stupka, E., Zanetti, G., Montini, E. - VISPA: a Computational pipeline for the identification and analysis of genomic vector integration sites. Genome Medicine 2014, 6:67 - doi:10.1186/s13073-014-0067-5
  • Calabria, A., Spinozzi, G., Benedicenti, F., Tenderini, E., Montini, E. - adLIMS: a customized open source software that allows bridging clinical and basic molecular research studies. BMC Bioinformatics 2015, 16(Suppl 9):S5 - doi:10.1186/1471-2105-16-S9-S5
  • Visigalli, I., Delai, S., Ferro, F., Cecere, F., Vezzoli, M., Sanvito, F., Benedicenti, F., Spinozzi, G., Calabria, A., Naldini, L., Montini, E., Cristofori, P., Biffi, A. - Preclinical test- ing of the safety and tolerability of LV-mediated above normal alpha-L-iduronidase expression in murine and human hematopoietic cells using toxicology and biodistribution GLP studies. Human Gene Therapy October 2016, 27(10): 813-829 - doi:10.1089/hum.2016.068 

  • Spinozzi, G.*, Calabria, A.*, Brasca, S., Beretta, S., Merelli, I., Milanesi, L., Montini, E. - VISPA2: A Scalable Pipeline for High-Throughput Identification and Annotation of Vector Integration Sites. BMC Bioinformatics 18 (1), 520 - doi:10.1186/s12859-017-1937-9

     

Conference Proceedings
  • Spinozzi, G., Calabria, A., Caravagna, G., Graudenzi, A., Ramazzotti, D., Antoniotti, M., Mauri, G., Montini, E. - Investigating Drug-Resistance in Cancer with a new Mathematical Framework for the Inference of Cancer Progression Models and Vector Integration Sites Data. 23rd Annual International Conference on Intelligent Systems for Molecular Biology and the 14th European Conference on Computational Biology, 2015
  • Calabria, A., Spinozzi, G., Brasca, S., Beretta, S., Merelli, I., Benedicenti, F., Tenderini, E., Milanesi, L., Montini, E. - A New Bioinformatics Pipeline for Retroviral Integration Site Analysis in Hematopoietic Stem Cell Gene Therapy Applications}. Bioinformatics Italian Society, annual meeting 2015 - Oral Session
  • Pirazzoli, V., Biavasco, R., Spinozzi, G., Bertotti, A., Trusolino, L., Montini, E. - Uncovering Mechanisms of Resistance to Cetuximab by Insertional Mutagenesis in Heterotopically-Engrafted Human Colorectal Cancers. American Society of Gene & Cell Therapy (ASGCT) 2015 - Oral Session
  • Calabria, A., Brasca, S., Spinozzi, G., Benedicenti, F., Tenderini, E., Neduva, V., Govani, F., Dow, D., Montini, E. - A new bioinformatics tool to improve precision and quality of vector integration site identification after genomic alignment. European Society of Gene & Cell Therapy (ESGCT) 2015
  • Calabria, A., Brasca, S., Spinozzi, G., Benedicenti, F., Tenderini, E., Montini, E. - Density-based methods improve vector integration site identification quality. Eleventh international meeting on Computational Intelligence methods for Bioinformatics and Biostatistics (CIBB) 2014
  • Calabria, A., Benedicenti, F., Brasca, S., Spinozzi, G., Tenderini, E., Neduva, V., Dow, D., Montini, E. - Novel bioinformatic framework for quantification of retroviral integration sites from genomic DNA sonication-based PCR data. American Society of Gene & Cell Therapy (ASGCT) 2014
  • Calabria, A., Spinozzi, G., Benedicenti, F., Tenderini, E., Biasco, L., Montini, E. - adLIMS: a customized open source software that allows bridging clinical and basic molecular research studies. Bioinformatics Italian Society, annual meeting 2014
  • Calabria, A., Brasca, S., Spinozzi, G., Stupka, E., Naldini, L., Montini, E. - Vector Integration Site Identification through Density-based methods. Bioinformatics Italian Society, annual meeting 2014
  • Spinozzi, G., Calabria, A., Benedicenti, F., Tenderini, E., Brasca, S., Naldini, L., & Montini, E. - adLIMS : a new open source software allows bridging clinical and basic molecular research studies. OSR Scientific Retreat 2013
  • Calabria, A., Brasca, S., Spinozzi, G., Benedicenti, F., Biasco, L., Stupka, E., Naldini, L., Montini, E. - Bioinformatic Framework for Vector Integration Sites Analysis and Clonal Abundance Estimation. European Society of Gene and Cell Therapy (ESGCT)
  • Benedicenti, F., Calabria, A., Spinozzi, G., Brasca, S., Lazarevic, D., Tenderini, E., Govani, F., Stupka, E., Naldini, L., Doe, D., Montini, E. - A quantitative method for vector integration site retrieval based on genomic DNA sonication and Illumina next generation sequencing. European Society of Gene and Cell Therapy (ESGCT)
Address and contacts

Centro Ricerche Emato-Oncologiche (CREO)

Department of Medicine, Hematology

Ospedale Santa Maria della Misericordia
Building R (CREO), 2nd Floor
Piazzale Menghini 8/9, I-06132 Perugia (PG), Italy
email: giulio.spinozzi [at] unipg.it

 



San Raffaele Telethon Institute for Gene Therapy, SR-Tiget

Vector Integration Core
Via Olgettina, 58, I-20132 Milano (MI), Italy
Office: +39 02 2643 9301
E-Mail: spinozzi.giulio [at] hsr.it

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